“combined Multi-scale Modeling and Experimental Study of Bacterial Swarming and Blood Clot Formation”

Surface mo lity such as swarming is thought to precede biofilm forma on during spread of infec on. Popula on of swarming bacteria P. aeruginosa, major infec on in hospitals, will be shown to efficiently propagate as high density waves that move symmetrically as rings within swarms towards the extending tendrils. Mul -scale model simula ons suggested a cell-cell coordina on mechanism of wave propaga on which was recently shown to moderate swarming direc on of individual bacteria to avoid an bio cs [1]. Then a novel model [2] will be discussed which systemically couples bacterial, extracellular polymeric substances (EPS) and solvent phases in a biofilm.